Endoplasmic Reticulum Ca Handling in Excitable Cells in Health and Disease
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چکیده
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منابع مشابه
Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease.
The endoplasmic reticulum (ER) is a morphologically and functionally diverse organelle capable of integrating multiple extracellular and internal signals and generating adaptive cellular responses. It plays fundamental roles in protein synthesis and folding and in cellular responses to metabolic and proteotoxic stress. In addition, the ER stores and releases Ca(2+) in sophisticated scenarios th...
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Mitochondria have long been known to sequester cytosolic Ca and even to shape intracellular patterns of endoplasmic reticulum -based Ca signaling. Accumulating evidence suggests that the mitochondrial network is an excitable medium which can demonstrate Ca induced Ca release via the mitochondrial permeability transition. The role of this excitability remains unclear, but mitochondrial Ca handli...
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Background: Defects in endoplasmic reticulum homeostasis are common occurrences in different diseases, such as diabetes, in which the function of endoplasmic reticulum is disrupted. It is now well established that ion channels of endoplasmic reticulum membrane have a critical role in endoplasmic reticulum luminal homeostasis. Our previous studies showed the presence of an ATP-sensitive cationic...
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The spatial and temporal regulation of cellular calcium signals is modulated via two main Ca(2+) entry routes. Voltage-gated Ca(2+) channels (VGCC) and Ca(2+)-release activated channels (CRAC) enable Ca(2+) flow into electrically excitable and non-excitable cells, respectively. VGCC are well characterized transducers of electrical activity that allow Ca(2+) signaling into the cell in response t...
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Question: Why do excitable cells express store-operated Ca channels and nonexcitable cells express voltage-gated Ca channels (VGCCs)? Background: Ca release-activated Ca (CRAC) Orai channels increase intracellular Ca concentrations in response to depletion of endoplasmic reticulum (ER) Ca stores via a stromal interaction molecule 1 (STIM1)-dependent mechanism. VGCCs, suchas Cav1.2 channels, inc...
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